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References: Apovian, C
Gradual dose escalation is recommended to minimize side effects
Tirzepatide 15 mg (Mounjaro/Zepbound) produced 22.5% mean weight loss at 72 weeks in SURMOUNT-1 (N=2,539) [14]
October 21, 2025
Additional safety considerations include: Acute pancreatitis risk : Patients should be monitored for severe abdominal pain Gallbladder disease : Including cholelithiasis and cholecystitis Dehydration and acute kidney injury : Particularly with gastrointestinal side effects Hypoglycemia : When used with insulin or sulfonylureas in patients with diabetes Diabetic retinopathy complications : Particularly with semaglutide in patients with pre-existing retinopathy Patients with hypothyroidism should undergo thyroid function monitoring when starting weight loss injections
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